Greenville is a city and the county seat of Meriwether County, Georgia, United States. The population was 794 at the 2020 census, down fro…Greenville is a city and the county seat of Meriwether County, Georgia, United States. The population was 794 at the 2020 census, down from 876 in 2010. The city is located 60 miles southwest of Atlanta and is part of the Atlanta metropolitan area.