Viral Vector Production: Optimizing Processes - BioProcess …
WEBDec 17, 2020 · The company optimized its plasmid design, lentiviral manufacturing process, and quality control assays to enable a scalable, high-titer vector-production system. Some companies use a p24 enzyme-linked immunosorbent assay (ELISA) physical titer for measuring protein (a method that does not provide an indication of vector performance).
mRNA process allows speedy COVID vax scale-up - Bioprocess …
WEBSep 23, 2020 · The cell-free and enzymatic nature of its mRNA technology has allowed Moderna to quickly build a relatively small network capable of supporting commercial manufacture of its COVID-19 vaccine. On Monday, President Trump named Pfizer and J&J as leading the way in bringing a coronavirus vaccine to market. But also speaking …
Drivers, Opportunities, and Limits of Continuous Processing
WEBMar 20, 2017 · REGISTER TO DOWNLOAD. Figure 1: Drivers of continuous processing success. Biologics represent a significant group of approved drugs, and they are expected to continue their exceptional growth in the foreseeable future. At first glance, innovative monoclonal antibodies (MAbs) and their derivatives seem to dominate the field; …
Re-Imagining Chromatography - BioProcess International
WEBOct 17, 2023 · Where Do I Start? Normally, a stepwise approach is taken to minimize disruptions, digest these innovations, and build a technology experience. Identify Your Main Bottlenecks: A good starting point is identifying the major constraints in the process and manufacturing suites. If supply chain tension, stock challenges, and high CoGs are …
Downstream Processing recent news | BioProcess International
WEBLearn from the brightest minds in bioprocessing! The BPI US 2024 scientific agenda includes 200+ of the industry's top scientists to present the latest updates on how to improve efficiencies across all phases of biopharmaceutical development and production.
Analytical recent news | BioProcess International
WEBBenefits of Process Control for Combination Products: From Cost and Compliance to Unexpected Efficiencies Benefits of Process Control for Combination Products: From Cost and Compliance to Unexpected Efficiencies. Continuous data monitoring in process control enables biomanufacturers to detect variability early, allowing real-time adjustments to …
cSDS Electrophoresis: Toward Clone Selection - BioProcess …
WEBSep 23, 2020 · Here, we present how we applied capillary sodium-dodecyl sulfate (cSDS) electrophoresis, surface-plasmon resonance (SPR), and size-exclusion high-performance liquid chromatography (SE-HPLC) to monitor the quality of IgG produced during clone selection and bioreactor optimization. Bioreactor harvests were provided by our …
Recombinant Protein: E. coli-Based Expression - BioProcess …
WEBSep 22, 2020 · Our company’s internal efforts on recombinant restriction enzymes soon paid off. In 1982, PstI became the first product cloned and expressed by NEB scientists. A recombinant E. coli strain overexpressed about 100× more than the native organism. That allowed the company to reduce the unit price of PstI by 20-fold.
Recent publications | page 1 of 13 | BioProcess International
WEBSep 23 - Sep 26, 2024. Sep 23 - Sep 26, 2024. Learn from the brightest minds in bioprocessing! The BPI US 2024 scientific agenda includes 200+ of the industry's top scientists to present the latest updates on how to improve efficiencies across all phases of biopharmaceutical development and production. Learn More.
Bioprocess Sustainability: Collaborations - BioProcess International
WEBMay 30, 2023 · Sustainability initiatives are launching across the biopharmaceutical industry as companies begin to scrutinize their environmental impacts as part of the growing environmental, social, and governance (ESG) movement in business.